Key result
The calponin-homology (CH) domain in Vav and other signalling proteins is proposed to mediate association with filamentous actin, correlating with their control on G-proteins Rac and Rho.
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Identifies the CH domain as a potential F-actin binding region in signalling proteins like Vav, linking them to cytoskeleton organization via G-proteins.
An actin-binding protein domain we call here 'calponin-homology' or CH is present in signalling proteins such as Vav which are involved in activation and inactivation of small G-proteins. Using profile methods, we have detected two repeats of this domain in the actin-binding region of alpha-actinin and related proteins. Based on this, we propose that CH domain in Vav and other signalling proteins is employed for association with filamentous actin, and that this function correlates with their control on the G-proteins Rac and Rho which are involved in the organization of cytoskeleton.
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Castresana et al. (1995) studied this question. Vav CH domain was evaluated. The calponin-homology (CH) domain in Vav and other signalling proteins is proposed to mediate association with filamentous actin, correlating with their control on G-proteins Rac and Rho.
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