Intramolecular Reactions of Temporarily Silicon-Tethered Molecules

All articles of this category The Temporary Silicon Connection transforms a potential inter molecular reaction into an intra molecular one, by transiently connecting both partners through a silicon linkage. In addition to entropic advantages, temporary connectivity forces regioselectivity and high stereoselectivity often results. Applications in radical cyclizations, cycloadditions, nucleophilic delivery, and hydrosilylation are discussed. Connection is also ensured by the coordination of an aldehyde to a Lewis acidic silicon and has served in aldol and allylation reactions.