Key result
Cognitive dysfunction in patients with heart failure was independently associated with functional disability (OR 6.49; 95% CI 4.39-9.59).
Why the study?
Is cognitive dysfunction associated with functional disability in patients with heart failure?
Population
1583 patients with heart failure, without cerebrovascular disease, previous stroke, or Alzheimer's disease
Comparison
Cognitive dysfunction vs No cognitive dysfunction
Design
Cross-sectional
Authors
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Cognitive dysfunction may underlie disability in HF; hypothesis-generating and requires prospective confirmation before practice change.
Cross-Sectional (n=1,583)
Yes
Is cognitive dysfunction associated with functional disability in patients with heart failure?
Odds Ratio: 6.49 (95% CI 4.39–9.59)
Absolute Event Rate: 63.9% vs 16.8%
p-value: p=<0.0001
Cognitive dysfunction is strongly and independently associated with functional disability in heart failure patients, highlighting the need for early recognition and management.
Giuseppe Zuccalà (2001) conducted a cross-sectional in heart failure (n=1,583). Cognitive dysfunction vs. No cognitive dysfunction was evaluated on functional disability (need for intensive assistance in at least one of Katz' activities of daily living) (OR 6.49, 95% CI 4.39-9.59, p=<0.0001). Cognitive dysfunction in patients with heart failure was independently associated with functional disability (OR 6.49; 95% CI 4.39-9.59).
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