Key result
Older age (≥ 45 years) was independently associated with a significantly higher likelihood of abnormal echocardiography compared to young adults (90.7% vs 44.7%, aOR 7.5).
Why the study?
Cardiovascular diseases are increasing worldwide and lifestyle CVDs are rising in Sub-Saharan Africa including Tanzania, but the spectrum of CVDs among young versus older adults needed determination.
Cross-Sectional (n=1,050)
No
Hypertensive heart disease is the predominant echocardiographic diagnosis among both young and older adults referred for echocardiography in Tanzania, highlighting the critical need for early hypertension detection and management.
Supports age-stratified echo prioritization among referred adults; leaves open generalizability and impact on outcomes in unselected cohorts.
BACKGROUND: Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality worldwide, with data showing an increasing trend. Previously uncommon, CVDs of lifestyle are now increasing in many Sub-Sahara African (SSA) countries including Tanzania. The study aimed at determining the spectrum and distribution of CVDs among young (< 45 years) and older (≥ 45 years) adults referred for echocardiography at Jakaya Kikwete Cardiac Institute (JKCI). METHODS: Hospital-based cross sectional study was conducted among adult patients referred for echocardiography at JKCI between July and December 2021. Patient's socio-demographic and clinical characteristics were recorded. CVD diagnoses were made using established diagnostic criterias. Comparisons were done using chi-square test and student's t-test. Multivariable logistic regression analysis was used to determine factors associated with abnormal echocardiography. A significance level was set at p-value < 0.05. RESULTS: In total 1,050 patients (750 old and 300 young adults) were enrolled. The mean ± SD age was 62.2 ± 10.4 years and 33.5 ± 7.4 years for older and young adults respectively. Hypertension was the commonest indication for echocardiography both in the young (31%) and older (80%) adults. Majority of older adults were found to have abnormal echocardiography (90.7%), while only 44.7% of the young adults had abnormal echocardiography (p < 0.001). For the older adults, the commonest diagnoses were HHD (70.3%), IHD (9.7%), and non-ischemic cardiomyopathy (6.1%) while for young adults, HHD (16.7%), non-ischemic cardiomyopathy (8%), RHD (8%) and MVP (4.3%) were the commonest. The differences in the echocardiographic diagnoses between young and older adults were statistically significant, p < 0.001. Being an older adult, hypertensive, overweight/obese were independently associated with abnormal echocardiography (p < 0.01). CONCLUSION: Hypertensive heart disease is the most common diagnosis among adult patients referred for echocardiography at JKCI, both in young and older adults. Primary prevention, early detection and treatment of systemic hypertension should be reinforced in order to delay or prevent its complications.
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Jonathan et al. (2023) conducted a cross-sectional in Cardiovascular diseases (n=1,050). Older age (≥ 45 years) vs. Young adults (< 45 years) was evaluated on Abnormal echocardiography (aOR 7.5, 95% CI 5.1-11.0, p=<0.001). Older age (≥ 45 years) was independently associated with a significantly higher likelihood of abnormal echocardiography compared to young adults (90.7% vs 44.7%, aOR 7.5).
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