Key result
Prescription of ACE inhibitors was independently associated with cognitive stability in amnestic MCI, with overall antihypertensive use being greater in stable versus progressive patients (P=0.01).
Why the study?
Does Angiotensin Converting Enzyme (ACE) Inhibitors prevent memory decline in subjects with amnestic mild cognitive impairment?
Population
74 subjects consecutively recruited who met the operational criteria for amnestic mild cognitive impairment
Design
Cohort
Follow-up
1 year
Authors
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Risk factors for MCI progression remain imprecise; leaves open reliable prediction models pending validation.
Cohort (n=74)
Does Angiotensin Converting Enzyme (ACE) Inhibitors prevent memory decline in subjects with amnestic mild cognitive impairment?
In patients with amnestic mild cognitive impairment, the prescription of ACE inhibitors is associated with a lower risk of cognitive deterioration at 1 year.
Rozzini et al. (2006) conducted a cohort in amnestic mild cognitive impairment (n=74). Angiotensin Converting Enzyme (ACE) Inhibitors vs. Non-use of ACE inhibitors was evaluated on Progression of memory decline (progressive vs stable MCI). Prescription of ACE inhibitors was independently associated with cognitive stability in amnestic MCI, with overall antihypertensive use being greater in stable versus progressive patients (P=0.01).
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