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Climate adaptation genomics of cattle. We comparatively analyzed genomic data from 85 Old World cattle breeds/populations of Eurasia and Africa to identify genetic factors associated with climate factors. Environmental genome-wide association studies revealed 3165 single-nucleotide polymorphisms (SNPs) with strong correlations between climate factors and allele frequencies. We also identified loci that were significantly associated with temperature factors in the regulatory regions, such as promoter regions, of genes (ANKRD11, RPL13, CDK10, and VPS9D1) under strong selection pressure on Bos taurus autosome 18, which might regulate the expression of these genes. These significantly associated SNPs could be used as potential resources for marker-assisted breeding programs aimed at climate resilience and sustainable cattle production under changing environmental conditions.
Sun et al. (Sun,) studied this question.