Key result
KCNE1 deletion in mice increased outward K+ current in atrial myocytes, shortened atrial action potentials, and enhanced susceptibility to spontaneous episodes of atrial fibrillation.
Why the study?
Does KCNE1 deletion increase susceptibility to atrial fibrillation in mice?
Population
KCNE1-null mice (KCNE1-/-) and CHO cells expressing KCNQ1 and KCNE1
Comparison
Deletion of KCNE1 protein partner vs Control mice and CHO cells expressing KCNQ1 alone
Design
Preclinical
Authors
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Should not change AF care; hypothesis-generating for KCNE1 in arrhythmia models.
Does KCNE1 deletion increase susceptibility to atrial fibrillation in mice?
Deletion of KCNE1 in mice shortens atrial action potentials and increases outward potassium currents, enhancing susceptibility to atrial fibrillation.
Temple et al. (2005) studied Atrial Fibrillation. KCNE1 deletion vs. controls was evaluated on Atrial action potentials and susceptibility to atrial fibrillation. KCNE1 deletion in mice increased outward K+ current in atrial myocytes, shortened atrial action potentials, and enhanced susceptibility to spontaneous episodes of atrial fibrillation.
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