Key result
In-hospital ventricular arrhythmias are linked to ~3.9-fold higher long-term adverse cardiac events in Takotsubo syndrome.
Why the study?
Although Takotsubo syndrome is generally considered reversible, early arrhythmias are a dreaded complication and their prognostic significance remains incompletely understood.
Cohort (n=104)
No
Odds Ratio: 3.94 (95% CI 1.22–12.69)
p-value: p=0.021
Early in-hospital ventricular arrhythmias are a strong, independent predictor of adverse long-term cardiac outcomes in patients with Takotsubo syndrome, emphasizing the need for structured rhythm monitoring.
May support closer monitoring in Takotsubo syndrome; leaves open whether targeted interventions improve outcomes.
Background: Takotsubo syndrome (TTS) is an acute cardiac condition characterized by transient left ventricular dysfunction. Although generally considered reversible, early arrhythmias are a dreaded complication and their prognostic significance remains incompletely understood. Methods: In this study, 104 consecutive patients diagnosed with TTS (January 2007 to September 2024) were examined for the prognostic relevance of in-hospital arrhythmias during monitoring at the time of diagnosis. The median follow-up was 2.1 years. The primary combined endpoint included cardiac death, TTS recurrence, occurrence of arrhythmias, and rehospitalization for cardiac causes. Results: In-hospital arrhythmias occurred in 35.6% of the patients. Ventricular arrhythmias were significantly associated with an increased risk of adverse cardiac events (odds ratio 3.94, 95% confidence interval 1.22–12.69; p = 0.021). Reduced left ventricular ejection fraction and QTc prolongation, while frequently observed, were not independently associated with adverse outcomes when analyzed separately from arrhythmic events. Supraventricular arrhythmias exhibited a non-significant trend (p = 0.145). Conclusions: In a large registry of consecutive TTS patients, in-hospital ventricular arrhythmias at diagnosis were significantly associated with adverse outcomes, underscoring the importance of early rhythm monitoring.
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Güler-Eren et al. (2025) conducted a cohort in Takotsubo syndrome (n=104). In-hospital ventricular arrhythmias vs. Absence of ventricular arrhythmias was evaluated on Composite of cardiac death, TTS recurrence, occurrence of arrhythmias, and rehospitalization for cardiac causes (OR 3.94, 95% CI 1.22-12.69, p=0.021). In-hospital ventricular arrhythmias were significantly associated with an increased risk of long-term adverse cardiac events (OR 3.94) in patients with Takotsubo syndrome.
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