Key result
Doubling the stiffness of a microvessel in a computational fluid-structure interaction model increased blood pressure by approximately 12% and reduced vessel deformation by half.
Why the study?
The effect of microvessel stiffness on blood pressure and blood flow-induced wall shear stress was investigated to better understand cardiovascular disease roots in micron-sized vessels.
Does increased microvessel stiffness alter blood pressure and wall shear stress in computational models?
Does increased microvessel stiffness alter blood pressure and wall shear stress in computational models?
Computational fluid-structure interaction modeling demonstrates that increased microvessel stiffness directly increases blood pressure and wall shear stress while reducing deformation capability.
Microvessel stiffness models may guide mechanistic hypotheses; leaves open clinical relevance pending validation.
The exploits of computer modelling in the study of cardiovascular disease have recently gained significant progress. In this study, the effect of microvessels stiffness on blood pressure and blood flow-induced wall shear stress (WSS) was analysed numerically. Three microvessels in diameters of 100, 200 and 300 microns with respectively media thicknesses of 10, 20 and 30 microns, were designed. Then for each model as material properties, the elastic modulus of 0.4, 0.6 and 0.8 MPa was applied. The blood flow within the microvessels was investigated using CFD analysis. A fluid-structure interaction (FSI) multiphysics analysis was performed to observe the effect of vascular stiffness on blood pressure and vice versa the effect of blood flow on the microvessel deformation. The result of the analysis showed that increasing the stiffness of the vessel increases blood pressure and WSS, and as well as causes a decline in its deformation capability. The outcome of this theoretical study shed more light on understanding cardiovascular diseases roots and origin, especially in micron-sized vessels.
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Davar Ali (2020) studied Hypertension. Increased microvessel stiffness vs. Lower microvessel stiffness was evaluated on Blood pressure, wall shear stress, and vessel deformation. Doubling the stiffness of a microvessel in a computational fluid-structure interaction model increased blood pressure by approximately 12% and reduced vessel deformation by half.
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