What is the clinical evidence from this study?

Study design: Cohort. Population: Hospitalized stroke (n=10399). Intervention: Hospitalized stroke. Primary outcome: Composite events of recurrent stroke, MI, or vascular death at 4 years.

What question did this study set out to answer?

The study aims to assess the risks of recurrent stroke, myocardial infarction, vascular death, and all-cause death in hospitalized stroke patients.

February 16, 2010Neurology

Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients

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Key result

Hospitalized stroke patients faced a 41.3% cumulative risk of recurrent stroke, MI, or vascular death at 4 years, with higher risk in African Americans (HR 1.12) and those with more comorbidities.

Population

10,399 patients with a primary diagnosis of stroke discharged in 2002 from the South Carolina state hospital…

Design

Cohort

Follow-up

4 years

Authors

WFWuwei FengDuke University RHRobert M. HendryMedical University of South Carolina RARobert AdamsAdelaide Institute for Sleep Health

Discussion

Member takes

Implication

Long-term post-stroke event rates remain high in real-world data; leaves open optimal secondary prevention strategies.

Key Points

The study aims to assess the risks of recurrent stroke, myocardial infarction, vascular death, and all-cause death in hospitalized stroke patients.
Identified patients with primary stroke diagnosis from the South Carolina hospital discharge database in 2002.
Calculated Kaplan-Meier estimates of various outcomes over several years.
Assessed prognostic factors using multivariate Cox proportional hazard models.
Cumulative risk estimates for recurrent stroke increased from 1.8% at 1 month to 18.1% at 4 years.
Hazard ratio for composite events related to age is 1.38, indicating higher risk with older age.
Hazard ratios also higher for African Americans (1.12) and patients with a higher comorbidity index (> or = 2) at 1.67.

Study Design

Type

Cohort (n=10,399)

Multicenter

Yes

Structured PICO

Population

10,399 patients with a primary diagnosis of stroke discharged in 2002 in South Carolina, followed for up to 4 years.

Outcome

Recurrent stroke, myocardial infarction, vascular death, all-cause death, and composite events at 1 month, 6 months, 1 year, 2 years, 3 years, and 4 yearshard clinical

Hospitalized stroke patients face a high long-term risk of recurrent cardiovascular events and death, highlighting the need for improved secondary prevention strategies.

Cite This Study

Feng et al. (2010) conducted a cohort in Hospitalized stroke (n=10,399). Hospitalized stroke was evaluated on Composite events of recurrent stroke, MI, or vascular death at 4 years. Hospitalized stroke patients faced a 41.3% cumulative risk of recurrent stroke, MI, or vascular death at 4 years, with higher risk in African Americans (HR 1.12) and those with more comorbidities.

synapsesocial.com/papers/6a600ef484fc82cc78003bd9 https://doi.org/10.1212/wnl.0b013e3181cff776

View Full Paper

Ask AI

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February 16, 2010Neurology

Risk of recurrent stroke, myocardial infarction, or death in hospitalized stroke patients

View Full Paper

Ask AI

Bookmark

Key result

Hospitalized stroke patients faced a 41.3% cumulative risk of recurrent stroke, MI, or vascular death at 4 years, with higher risk in African Americans (HR 1.12) and those with more comorbidities.

Population

10,399 patients with a primary diagnosis of stroke discharged in 2002 from the South Carolina state hospital…

Design

Cohort

Follow-up

4 years

Authors

WFWuwei FengDuke University RHRobert M. HendryMedical University of South Carolina RARobert AdamsAdelaide Institute for Sleep Health

Discussion

Member takes

Implication

Long-term post-stroke event rates remain high in real-world data; leaves open optimal secondary prevention strategies.

Key Points

The study aims to assess the risks of recurrent stroke, myocardial infarction, vascular death, and all-cause death in hospitalized stroke patients.
Identified patients with primary stroke diagnosis from the South Carolina hospital discharge database in 2002.
Calculated Kaplan-Meier estimates of various outcomes over several years.
Assessed prognostic factors using multivariate Cox proportional hazard models.
Cumulative risk estimates for recurrent stroke increased from 1.8% at 1 month to 18.1% at 4 years.
Hazard ratio for composite events related to age is 1.38, indicating higher risk with older age.
Hazard ratios also higher for African Americans (1.12) and patients with a higher comorbidity index (> or = 2) at 1.67.

Study Design

Type

Cohort (n=10,399)

Multicenter

Yes

Structured PICO

Population

10,399 patients with a primary diagnosis of stroke discharged in 2002 in South Carolina, followed for up to 4 years.

Outcome

Recurrent stroke, myocardial infarction, vascular death, all-cause death, and composite events at 1 month, 6 months, 1 year, 2 years, 3 years, and 4 yearshard clinical

Hospitalized stroke patients face a high long-term risk of recurrent cardiovascular events and death, highlighting the need for improved secondary prevention strategies.

Cite This Study

synapsesocial.com/papers/6a600ef484fc82cc78003bd9 https://doi.org/10.1212/wnl.0b013e3181cff776

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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