Key result
Low liver attenuation and high pericardial adipose tissue were significantly associated with insulin resistance (regression coefficients 0.31 and 0.27, respectively; P<0.0001), independent of BMI.
Why the study?
Are liver attenuation and pericardial adipose tissue associated with insulin resistance independent of general and abdominal obesity in individuals free of clinical cardiovascular disease and diabetes?
Population
5,291 individuals free of clinical cardiovascular disease and diabetes in the Multi-Ethnic Study of…
Design
Cross-sectional
Authors
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Associations should not yet change practice; leaves open whether ectopic fat independently drives insulin resistance.
Cross-Sectional (n=5,291)
Yes
Are liver attenuation and pericardial adipose tissue associated with insulin resistance independent of general and abdominal obesity in individuals free of clinical cardiovascular disease and diabetes?
Effect estimate: regression coefficient 0.31
p-value: p=< 0.0001
Ectopic fat depots, specifically hepatic lipid content and pericardial adipose tissue, are associated with insulin resistance independently of traditional obesity measures.
McAuley et al. (2011) conducted a cross-sectional in Insulin resistance (n=5,291). Low liver attenuation and high pericardial adipose tissue was evaluated on Insulin resistance assessed by the homeostasis model assessment of insulin resistance (HOMA(IR)) index (regression coefficient 0.31, p=< 0.0001). Low liver attenuation and high pericardial adipose tissue were significantly associated with insulin resistance (regression coefficients 0.31 and 0.27, respectively; P<0.0001), independent of BMI.
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