Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment
Key result
Hypoxia-inducible factors (HIF-1 and HIF-2) are linked to protection against ischemic cardiovascular disease but contribute to the pathogenesis of pulmonary arterial hypertension.
Why the study?
What is the role of hypoxia-inducible factors (HIF-1 and HIF-2) in cardiovascular disease progression, prevention, and treatment?
Population
Patients with or experimental models of cardiovascular diseases including ischemic cardiovascular disease…
Design
Review
Authors
Discussion
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Member takes
Implication
HIF activation may protect against ischemic CV disease; leaves open whether modulators will translate clinically.
Structured PICO
What is the role of hypoxia-inducible factors (HIF-1 and HIF-2) in cardiovascular disease progression, prevention, and treatment?
P
Population
Patients with or experimental models of cardiovascular diseases including ischemic cardiovascular disease (coronary artery disease and peripheral artery disease) and pulmonary arterial hypertension
E
Exposure
Modulation (activation or inhibition) of Hypoxia-inducible factors (HIF-1 and HIF-2)
Modulating hypoxia-inducible factors (HIFs) presents a potential therapeutic strategy, with HIF activation being potentially beneficial for ischemic diseases and HIF inhibition for pulmonary arterial hypertension.
Cite This Study
Gregg L. Semenza (2022) conducted a review in Cardiovascular disease. Hypoxia-inducible factors (HIF-1 and HIF-2) was evaluated. Hypoxia-inducible factors (HIF-1 and HIF-2) are linked to protection against ischemic cardiovascular disease but contribute to the pathogenesis of pulmonary arterial hypertension.