Key result
A higher triglyceride glucose index was an independent risk factor for poor collateral circulation formation in patients with chronic total occlusion (OR 5.104), especially in those with prediabetes and diabetes.
Why the study?
The study sought to investigate the correlation between triglyceride glucose index and collateral circulation in patients with coronary chronic total occlusion across different glucose metabolic states.
Does the triglyceride glucose index correlate with poor collateral circulation formation in patients with chronic total occlusion across different glucose metabolic states?
Observational (n=681)
No
Does the triglyceride glucose index correlate with poor collateral circulation formation in patients with chronic total occlusion across different glucose metabolic states?
Odds Ratio: 5.104 (95% CI 3.323–7.839)
p-value: p=<0.001
A higher triglyceride glucose index is significantly associated with an increased risk of poor collateral circulation formation in patients with coronary chronic total occlusions, particularly in those with prediabetes and diabetes.
TyG index was associated with poor collaterals in CTO patients with Pre-DM or DM; leaves open its utility for risk stratification.
BACKGROUND: To investigate the correlation between triglyceride glucose index (TyG) and collateral circulation in patients with chronic total occlusion (CTO) of coronary arteries in different glucose metabolic states. METHODS: A total of 681 patients who underwent coronary angiography between January 2020 and December 2021 to determine the presence of CTO lesions in at least one major coronary artery were retrospectively included in this study. Patients were categorized into a group with poor collateral circulation formation (Rentrop grade 0-1, n = 205) and a group with good collateral circulation formation (Rentrop grade 2-3, n = 476) according to the Rentrop scale. They were also categorized according to their glucose metabolism status: normal glucose regulation (NGR) (n = 139), prediabetes mellitus (Pre-DM) (n = 218), and diabetes mellitus (DM) (n = 324). Correlation between TyG index and collateral circulation formation was analyzed by logistic regression analysis and receiver operating characteristic (ROC) curves. RESULTS: Among patients with CTO, TyG index was significantly higher in the group with poor collateral circulation formation than in the group with good collateral circulation formation. Logistic regression analysis showed that TyG index was an independent risk factor for poor collateral circulation formation (OR 5.104, 95% CI 3.323-7.839, P < 0.001). The accuracy of TyG index in predicting collateral circulation formation was evaluated by the ROC curve, which had an area under the curve of 0.779 (95% CI 0.738-0.820, P < 0.001). The restrictive cubic spline curves showed that the risk of poor collateral circulation formation in the Pre-DM and DM groups was initially flat and finally increased rapidly, except for the NGR group. TyG index was significantly associated with an increased risk of poor collateral circulation formation in the Pre-DM and DM groups. CONCLUSIONS: TyG index was significantly associated with the risk of poor collateral circulation formation in patients with CTO, especially those with Pre-DM and DM.
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Zhu et al. (2024) conducted an observational in Chronic total occlusion of coronary arteries (n=681). Triglyceride glucose (TyG) index vs. Lower TyG index was evaluated on Poor collateral circulation formation (Rentrop grade 0-1) (OR 5.104, 95% CI 3.323-7.839, p=<0.001). A higher triglyceride glucose index was an independent risk factor for poor collateral circulation formation in patients with chronic total occlusion (OR 5.104), especially in those with prediabetes and diabetes.
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