Key result
Higher plasma omentin-1 levels were independently associated with good coronary collateral circulation in patients with ≥90% coronary occlusion (OR 1.002, p=0.041).
Why the study?
Is plasma omentin-1 level associated with good coronary collateral circulation in patients with ≥90% coronary occlusion?
Cross-Sectional (n=142)
No
Is plasma omentin-1 level associated with good coronary collateral circulation in patients with ≥90% coronary occlusion?
Odds Ratio: 1.002 (95% CI 1–1.004)
p-value: p=0.041
Higher plasma omentin-1 levels are independently associated with better coronary collateral circulation in patients with severe coronary occlusion, suggesting its potential as a biomarker for adequate revascularization.
Higher omentin-1 may mark better CCC; leaves open biomarker or therapeutic roles pending larger prospective data.
AIM: Coronary collateral circulation (CCC) is crucial during an acute ischemic attack. Evidences showed that omentin-1 exhibited remarkable antiatherogenic effects and ischemia-induced revascularization. The aim of this study was to investigate the relationship between plasma omentin-1 levels and CCC in patients with ≥90% angiography-proven coronary occlusion. METHODS: 142 patients with ≥90% luminal diameter stenosis in at least one major epicardial coronary artery were recruited. Among them, 79 patients with Rentrop 0-1 grade were classified into the poor CCC group and 63 patients with Rentrop 2-3 grade were included into the good CCC group. The association between plasma omentin-1 levels and CCC status was assessed. RESULTS: Plasma omentin-1 level was significantly higher in patients with good CCC than those with poor CCC (566.57±26.90 vs. 492.38±19.70 ng/mL, p=0.024). Besides, omentin-1 was positively correlated with total cholesterol (TC), high-density lipoprotein, and gensini score but inversely with hyperlipidemia and body mass index (all p values＜0.05). Multivariate regression analysis indicated that omentin-1 [odds ratio (OR)=1.002, 95% confidence interval (CI): 1.000-1.004, p=0.041)], TC, the number of the diseased vessels, a higher frequency of left circumflex artery and right coronary artery, chronic total occlusion, and gensini score remained as the independent predictors of good CCC. CONCLUSION: Higher plasma omentin-1 level was associated with better CCC development. Our findings suggest that omentin-1 may be an alternative marker for adequate CCC in patients with ≥90% coronary occlusion.
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Zhou et al. (2017) conducted a cross-sectional in Coronary heart disease with ≥90% coronary occlusion (n=142). Plasma omentin-1 level vs. Lower plasma omentin-1 level was evaluated on Good coronary collateral circulation (Rentrop grade 2-3) (OR 1.002, 95% CI 1.000-1.004, p=0.041). Higher plasma omentin-1 levels were independently associated with good coronary collateral circulation in patients with ≥90% coronary occlusion (OR 1.002, p=0.041).
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