Key result
Patients with coronary artery disease had significantly lower plasma omentin-1 levels compared to patients without the disease (61.21 vs. 95.22 ng/dL, p<0.0001).
Why the study?
Omentin-1 contributes to the pathogenesis of chronic inflammatory diseases including cardiovascular events, but its association with CAD needed to be determined.
Are plasma omentin-1 levels associated with the presence of coronary artery disease?
Case-Control (n=600)
No
Are plasma omentin-1 levels associated with the presence of coronary artery disease?
Absolute Event Rate: 61.21% vs 95.22%
p-value: p=<0.0001
Plasma omentin-1 levels are significantly lower in patients with coronary artery disease, suggesting its potential utility as a biomarker for CAD development and progression.
Lower omentin-1 levels are associated with CAD; this case-control finding is hypothesis-generating and requires prospective validation before clinical use.
INTRODUCTION: Omentin-1 is secreted from visceral adipose tissue that contributes to chronic inflammatory diseases' pathogenesis, including cardiovascular events. In this case-control study, we will determine the association between plasma omentin and coronary artery disease (CAD). METHODS: This is a case-control study, conducted from June 2020 to April 2021 in the cardiology unit of a tertiary care hospital in Pakistan. Patients diagnosed with CAD (n = 300) within the last six months were included in the study. Another 300 participants without CAD and with similar demographic profiles were included in the control group. A blood sample of 5 ml was drawn from participants of both groups and sent to the laboratory to test for plasma omentin level. RESULTS: Plasma omentin level was significantly lower in patients with CAD compared to the patients without CAD (61.21 ± 10.21 ng/dL vs. 95.22 ± 12.21 ug/L; p-value: <0.0001). In both genders, the plasma omentin-1 was lower in patients with CAD compared to patients without CAD (p-value: <0.0001). CONCLUSION: The present study revealed a negative association between omentin-1 and CAD. We speculate that low levels of omentin-1 might play a role in the pathogenesis of atherosclerosis. Therefore, plasma omentin-1 can be a potential biomarker to predict the development and progression of CAD.
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Bai et al. (2021) conducted a case-control in Coronary Artery Disease (n=600). Coronary Artery Disease vs. Patients without CAD was evaluated on Plasma omentin-1 level (ng/dL) (p=<0.0001). Patients with coronary artery disease had significantly lower plasma omentin-1 levels compared to patients without the disease (61.21 vs. 95.22 ng/dL, p<0.0001).
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