This research focuses on developing a photoacoustic probe to identify superoxide anions in liver injury caused by ferroptosis.
Utilized a photoacoustic imaging system to measure the response of the probe in liver tissues.
Evaluated the specificity and sensitivity of the imaging signal in detecting superoxide anions during ferroptosis.
Assessed imaging effectiveness in an acute liver injury model.
The Rho-DOH probe exhibited a significant enhancement in imaging signal for superoxide anions (p<0.01).
Visualized tracing allowed for real-time monitoring of ferroptosis-related changes during liver injury.
Findings suggest that the probe can effectively facilitate diagnosis and treatment strategies for ferroptosis-associated liver conditions.
Abstract
-responsive PA imaging signal. These findings position Rho-DOH as a promising molecular imaging tool, offering robust support for the accurate diagnosis and treatment of ferroptosis-associated liver injury.