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July 22, 2026Medical SciencesOpen Access

Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas: History, Myths, and Realities Between Past and Future

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Authors

RUR. UrgesiCPCristiano PagniniMPMaria Carla Di Paolo

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Overview

Review highlights the complexities of IPMN management, focusing on molecular alterations and surveillance strategies.

Key Points

  • This review aims to clarify the evolving understanding and management of intraductal papillary mucinous neoplasm (IPMN).
  • Comprehensive synthesis of IPMN history, molecular pathogenesis, and clinical management.
  • Evaluation of international consensus guidelines on risk stratification and surgical decision-making.
  • Discussion of diagnostic evaluations and long-term complications associated with IPMN.
  • IPMN recognized as a precursor to pancreatic ductal adenocarcinoma, driven by specific molecular mutations.
  • Surveillance and management strategies are still debated, particularly for low-risk branch-duct lesions.
  • Historical myths around IPMN management have been challenged by recent clinical evidence.

Cite This Study

Urgesi et al. (2026) studied this question.

synapsesocial.com/papers/6a605d764163e025518d7800https://doi.org/10.3390/medsci14030405
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intraductal papillary mucinous neoplasms: a comprehensive analysis combining genetic, immunopathological and clinical management2026
  2. 2Portuguese Pancreatic Club perspective on epidemiology, classification and natural history of pancreatic intraductal papillary mucinous neoplasms2025
  3. 3Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas: current understanding and perspectives on malignant progression2025
  4. 4Intraductal papillary mucinous neoplasms of the pancreas associated with ductal carcinoma as two distinct clinical entities2025
  5. 5Periodic surveillance of intraductal papillary mucinous neoplasms: gaps in evidence and future directions2026