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Evaluate the feasibility of using dogs and pigs as models for assessing hepatic flux of gadolinium-based contrast agents.

Pharmacokinetic Modeling of Hepatospecific MRI Contrast Agent Flux in Large Animal Models by Dynamic Contrast-Enhanced MRI

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Randomized trial evaluates hepatic flux in dogs and pigs, suggesting strong translational model potential.

Evaluate the feasibility of using dogs and pigs as models for assessing hepatic flux of gadolinium-based contrast agents.
Performed dynamic contrast-enhanced MRI with hepatospecific agents Gd-EOB-DTPA and Gd-BOPTA.
Applied two pharmacokinetic models: single-input reference region and dual-input using arterial and venous signals.
Conducted imaging in large animal models (dogs and pigs).
In dogs, hepatic enhancement peaked rapidly after Gd-EOB-DTPA administration, with minimal decline (specific rates not provided).
In pigs, both hepatospecific agents showed a rapid rise, a blunt peak, and a gradual decline, indicating dynamic differences.
The single-input model showed higher uptake rates for hepatospecific agents and confirmed its sensitivity to hepatocyte uptake.

Latourette et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial evaluates hepatic flux in dogs and pigs, suggesting strong translational model potential.

Evaluate the feasibility of using dogs and pigs as models for assessing hepatic flux of gadolinium-based contrast agents.
Performed dynamic contrast-enhanced MRI with hepatospecific agents Gd-EOB-DTPA and Gd-BOPTA.
Applied two pharmacokinetic models: single-input reference region and dual-input using arterial and venous signals.
Conducted imaging in large animal models (dogs and pigs).
In dogs, hepatic enhancement peaked rapidly after Gd-EOB-DTPA administration, with minimal decline (specific rates not provided).
In pigs, both hepatospecific agents showed a rapid rise, a blunt peak, and a gradual decline, indicating dynamic differences.
The single-input model showed higher uptake rates for hepatospecific agents and confirmed its sensitivity to hepatocyte uptake.

Latourette et al. (2026) studied this question.

View Full Paper

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