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July 22, 2026PLoS ONEOpen Access

Preoperative CHF and coagulopathy linked to postoperative sepsis in ~3% of ovarian cancer surgeries.

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Why the study?

Postoperative sepsis is a significant complication after ovarian cancer surgery, but limited studies have explored its associated risk factors.

What is the incidence and what are the risk factors for postoperative sepsis following ovarian cancer surgery?

Population

39,049 patients aged 18 to 99 years undergoing ovarian cancer surgery

Comparison

Presence vs absence of postoperative sepsis

Design

Retrospective database study

Key result

Preoperative comorbidities such as congestive heart failure and coagulopathy were associated with postoperative sepsis, which occurred in 3.3% of patients undergoing ovarian cancer surgery.

Authors

YWYu WangJZJing ZhengQLQun Lv

Discussion

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Overview

Postoperative sepsis incidence rose slightly after ovarian cancer surgery with identifiable risk factors; leaves open prospective validation before guiding prevention.

Key Points

  • This study aims to assess the prevalence and identify risk factors of postoperative sepsis after ovarian cancer surgery.
  • Retrospective analysis of data from Nationwide Inpatient Sample (NIS) between January 2010 and December 2019.
  • Patients categorized by the presence or absence of postoperative sepsis.
  • Univariate and multivariable logistic regression analyses conducted to identify associated factors.
  • Among 39,049 patients, 1,288 cases of postoperative sepsis were identified, yielding an incidence rate of 3.3%.
  • Postoperative sepsis was linked to higher hospital charges, advanced age, prolonged length of stay, and increased in-hospital mortality.
  • Preoperative risk factors included congestive heart failure, coagulopathy, and metastatic cancer.

Study Design

Type

Observational (n=39,049)

Multicenter

Yes

Structured PICO

What is the incidence and what are the risk factors for postoperative sepsis following ovarian cancer surgery?

P
Population
39,049 patients aged 18 to 99 years who underwent ovarian cancer surgery between 2010 and 2019.
C
Comparator
Patients without postoperative sepsis
O
Outcome
Incidence of postoperative sepsis and associated risk factorshard clinical

Postoperative sepsis occurs in 3.3% of patients undergoing ovarian cancer surgery and is associated with significant morbidity, mortality, and healthcare costs.

Cite This Study

Wang et al. (2026) conducted an observational in Ovarian cancer (n=39,049). Preoperative risk factors (e.g., congestive heart failure, coagulopathy, metastatic cancer) vs. Absence of risk factors was evaluated on Postoperative sepsis. Preoperative comorbidities such as congestive heart failure and coagulopathy were associated with postoperative sepsis, which occurred in 3.3% of patients undergoing ovarian cancer surgery.

synapsesocial.com/papers/6a605e1c4163e025518d7f44https://doi.org/10.1371/journal.pone.0353675
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiological characteristics of postoperative sepsis2019 · 22 citations
  2. 2Risk Factors for Sepsis in Postoperative Patients2024 · 2 citations
  3. 3Postoperative Sepsis in the United States2010 · 199 citations
  4. 4Incidence, Risk Factors and Outcomes of Sepsis in Post-Craniotomy Critical Ill Patients2021
  5. 5Costs of Postoperative Sepsis2011 · 33 citations