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July 22, 2026BMC PsychiatryOpen Access

Increased brain glucose metabolism after anodal left DLPFC–right shoulder tDCS in ASD: an open-label pilot F-18 FDG PET/CT study

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Authors

KKKeattichai KeeratitanontBurapha UniversityDTDaris TheerakulpisutKhon Kaen UniversityNANarong AuvichayapatKhon Kaen University

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Implication

Open-label pilot study shows increased brain metabolism correlating with social improvement in adolescents with ASD.

Key Points

  • To assess the effects of anodal tDCS on brain glucose metabolism and social functioning in adolescents with ASD.
  • Six adolescents with high-functioning ASD underwent five daily sessions of anodal tDCS at 2 mA targeting the left DLPFC via a right shoulder montage.
  • Brain glucose metabolism was measured using F-18 FDG PET/CT before and after the intervention in 26 brain regions.
  • Social symptoms were evaluated using the ATEC social subscale.
  • Metabolic increases exceeding 10% were observed in the prefrontal lateral, parietal inferior, temporal mesial, and cerebellum (FDR-adjusted p < 0.05).
  • Negative correlations were found between ATEC social scores and metabolic increases in the left prefrontal lateral (r = -0.832, p = 0.040) and cerebellum (r = -0.868, p = 0.025).
  • No adverse events were reported during the study.

Cite This Study

Keeratitanont et al. (2026) studied this question.

synapsesocial.com/papers/6a605ea14163e025518d85d0https://doi.org/10.1186/s12888-026-08418-x
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