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July 22, 2026BMC Cardiovascular DisordersOpen Access

A 3-month individualized nurse-led intervention cuts adverse events ~68% vs routine care in HF.

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Why the study?

Heart failure causes high morbidity and impaired quality of life, and routine care may not fully address variable patient needs that tailored, nurse-led strategies in nutrition, activity, and psychosocial support could meet.

Does a 3-month individualized nurse-led intervention improve health outcomes and quality of life in adults with heart failure?

Population

Adults with HF (n = 110 per group)

Comparison

Routine care plus a 3-month individualized nurse-led program vs routine nursing care alone

Design

Prospective single-center parallel-group study using odd-even allocation

Follow-up

3-month

Key result

A 3-month individualized nurse-led intervention significantly reduced adverse events compared to routine care (6.36% vs. 20.0%; p=0.006) in patients with heart failure.

Authors

FLFengli LiuJZJiansi ZhangZLZhi Liu

Discussion

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Overview

Hypothesis-generating for nurse-led HF support; leaves open benefits versus routine care in larger trials.

Key Points

  • To evaluate the effectiveness of an individualized, nurse-led intervention that incorporates nutrition, graded exercise, and psychosocial support in heart failure patients.
  • Prospective, single-center, parallel-group design
  • Participants included 220 adults with heart failure assigned to control or intervention groups
  • Intervention group received a 3-month tailored program encompassing nutritional counseling, exercise guidance, and psychosocial support
  • Shortened symptom improvement time for dyspnea (2.05 vs. 2.57 days; p < 0.001)
  • Improved cardiac function metrics (LVEF, CO ↑; LVEDD, LVESD ↓; all p < 0.05)
  • Enhanced quality of life measured by SF-36 (75.43 vs. 66.43; p < 0.05)

Study Design

Type

RCT (n=220)

Randomization

Odd-even allocation method

Multicenter

No

Structured PICO

Does a 3-month individualized nurse-led intervention improve health outcomes and quality of life in adults with heart failure?

P
Population
220 adults with heart failure assigned to an individualized nurse-led intervention or routine care for 3 months.
I
Intervention
3-month individualized nurse-led program comprising customized nutritional counseling, staged exercise guidance, and structured psychosocial support with follow-up, added to routine care
C
Comparator
Routine nursing care
O
Outcome
Time to symptom resolution, cardiac function, arterial blood gases, nutritional status, psychological status, quality of life, and adverse events

Main Result

Absolute Event Rate: 6.36% vs 20%

p-value: p=0.006

An individualized, nurse-led intervention integrating nutrition, exercise, and psychosocial support improves symptoms, cardiac function, and quality of life while reducing adverse events in heart failure patients.

Cite This Study

Liu et al. (2026) conducted an RCT in Heart failure (n=220). Individualized nurse-led intervention vs. Routine nursing care was evaluated on Adverse events (p=0.006). A 3-month individualized nurse-led intervention significantly reduced adverse events compared to routine care (6.36% vs. 20.0%; p=0.006) in patients with heart failure.

synapsesocial.com/papers/6a6060394163e025518d8a2ehttps://doi.org/10.1186/s12872-026-06190-0
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