Key result
The VARC-2 consensus document provides updated standardized clinical endpoint definitions for transcatheter aortic valve implantation to improve comparability of study results.
Why the study?
As clinical experience with TAVI matured and expanded, certain original VARC clinical endpoint definitions became unsuitable or ambiguous, necessitating updated standardization for clinical trials.
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“VARC-3 has, I would say, the most-contemporary definitions for aortic valve replacement-related research for both procedural complications, mid-term outcomes, and long-term outcomes, including outcomes related to valve function and patient-centric outcomes. I believe it's a really good document that reflects the last 10 years of progress in the field. We put in a lot of time and effort to come up with clinically meaningful definitions to better classify outcomes and design relevant research.”
Adoption of updated TAVI definitions may standardize endpoint reporting; leaves open effects on actual patient outcomes pending validation.
Kappetein et al. (2012) conducted a review in Symptomatic severe aortic stenosis (AS). VARC-2 standardized endpoint definitions was evaluated on Standardized clinical endpoints (mortality, stroke, myocardial infarction, bleeding, acute kidney injury, vascular complications, conduction disturbances). The VARC-2 consensus document provides updated standardized clinical endpoint definitions for transcatheter aortic valve implantation to improve comparability of study results.