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January 23, 2014Clinical Psychology ReviewOpen Access

Self-help interventions significantly improved symptoms of depression in patients with physical illnesses compared to control conditions (SMD -0.13; 95% CI -0.25 to -0.02; p=0.02).

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Why the study?

Do self-help interventions improve symptoms of depression, anxiety, and psychological distress in patients with physical illnesses?

Population

4,211 patients with physical illness (pooled from 25 RCTs)

Comparison

Self-help interventions vs Control conditions

Design

Meta-analysis

Key result

Self-help interventions significantly improved symptoms of depression in patients with physical illnesses compared to control conditions (SMD -0.13; 95% CI -0.25 to -0.02; p=0.02).

Authors

FMFaith MatchamLRLauren RaynerJHJane Hutton

Discussion

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Overview

Supports offering self-help for depression in physical illness; confirms modest benefit across 25 RCTs.

Study Design

Type

Meta-Analysis (n=4,211)

Structured PICO

Do self-help interventions improve symptoms of depression, anxiety, and psychological distress in patients with physical illnesses?

P
Population
4,211 patients with physical illnesses across 25 randomised controlled trials evaluating self-help interventions for depression, anxiety, and psychological distress.
I
Intervention
Self-help interventions
C
Comparator
Control conditions
O
Outcome
Symptoms of depression, anxiety and psychological distresspatient reported

Main Result

Standardized Mean Difference: -0.13 (95% CI -0.25–-0.02)

p-value: p=0.02

Self-help interventions may provide a small but significant improvement in depression symptoms for patients with physical illnesses.

Cite This Study

Matcham et al. (2014) conducted a meta-analysis in Physical illnesses with symptoms of depression, anxiety, and psychological distress (n=4,211). Self-help interventions vs. Control conditions was evaluated on Symptoms of depression (SMD -0.13, 95% CI -0.25, -0.02, p=0.02). Self-help interventions significantly improved symptoms of depression in patients with physical illnesses compared to control conditions (SMD -0.13; 95% CI -0.25 to -0.02; p=0.02).

synapsesocial.com/papers/6a60d7ffb7af1b8d7098df82https://doi.org/10.1016/j.cpr.2014.01.005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of Cognitive Behavioural Self-Help for the Treatment of Depression and Anxiety in People with Long-Term Physical Health Conditions: a Systematic Review and Meta-Analysis of Randomised Controlled Trials2015 · 60 citations
  2. 2The effects of self-management interventions on depressive symptoms in adults with chronic physical disease(s) experiencing depressive symptomatology: a systematic review and meta-analysis2021 · 35 citations
  3. 3Primary care and community interventions for multimorbidity involving depression or anxiety: systematic review with meta-analysis2026 · 1 citations
  4. 4Systematic review and meta-analysis of psychological interventions for depression symptoms in young people with long-term physical health conditions2025
  5. 5Systematic review and meta-analysis of digital interventions for mental health in cancer patients and survivors2025 · 3 citations