Key result
Pregnancy significantly decreased the central chemoreflex ventilatory recruitment threshold for CO2 compared to nonpregnant controls (40.5 vs. 45.8 Torr).
Why the study?
Does pregnancy alter the central chemoreflex control of breathing in humans?
Population
22 subjects: 11 pregnant subjects and 11 nonpregnant control subjects, equated for mean age, body height…
Comparison
Pregnancy (observational physiological study) vs Nonpregnant control subjects
Design
Case-control
Authors
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Increased central chemoreflex sensitivity in late pregnancy may alter ventilatory responses; leaves open clinical relevance and need for prospective validation.
Cross-Sectional (n=22)
Does pregnancy alter the central chemoreflex control of breathing in humans?
Absolute Event Rate: 40.5% vs 45.8%
Jensen et al. (2005) conducted a cross-sectional in Pregnancy (n=22). Pregnancy vs. Nonpregnant controls was evaluated on Central chemoreflex ventilatory recruitment threshold for CO2 (VRTco2). Pregnancy significantly decreased the central chemoreflex ventilatory recruitment threshold for CO2 compared to nonpregnant controls (40.5 vs. 45.8 Torr).