Key result
Combined induction of acute cerebral and myocardial ischemia in chronically hypertensive and arteriosclerotic male rats resulted in 100% mortality within 4 hours.
Population
Repeatedly bred male Sprague-Dawley rats with spontaneous arteriosclerosis, subjected to unilateral…
Design
Preclinical
Follow-up
4 hours post-isoproterenol injection
Authors
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Extreme lethality in this rat model warrants caution against generalization; leaves open human relevance of dual cerebral-myocardial ischemia.
Combined acute cerebral and myocardial ischemia in a hypertensive, arteriosclerotic rat model results in rapid mortality and severe physiological stress, potentially mediated by the hypothalamic-pituitary-adrenal axis.
Bernard C. Wexler (1977) studied Arteriosclerosis, severe hypertension, acute cerebral and myocardial ischemia. Combined induction of severe hypertension, acute cerebral ischemia, and acute myocardial ischemia was evaluated on Mortality within 4 hours of isoproterenol injection. Combined induction of acute cerebral and myocardial ischemia in chronically hypertensive and arteriosclerotic male rats resulted in 100% mortality within 4 hours.
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