September 12, 2017Catheterization and Cardiovascular Interventions
Early leaflet thrombosis complicating transcatheter implantation of a Sapien 3 valve in a native right ventricular outflow tract
Key result
Transcatheter implantation of a Sapien 3 valve in a native right ventricular outflow tract was complicated by early leaflet thrombosis, which resolved after a 6-week course of warfarin therapy.
Why the study?
Does oral anticoagulation with warfarin resolve early leaflet thrombosis complicating transcatheter implantation of a Sapien 3 valve in a native RVOT?
Population
59-year-old female with Tetralogy of Fallot, previous complete repair with RVOT patch enlargement, severe…
Design
Case_report
Follow-up
10 weeks
Authors
Discussion
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Member takes
Implication
May offer percutaneous valve option for inoperable repaired-TOF patients; case experience leaves durability and selection criteria open.
Study Design
Type
Case Report (n=1)
Structured PICO
Does oral anticoagulation with warfarin resolve early leaflet thrombosis complicating transcatheter implantation of a Sapien 3 valve in a native RVOT?
P
Population
A 59-year-old female with Tetralogy of Fallot and severe pulmonary regurgitation who underwent transcatheter pulmonary valve implantation.
I
Intervention
Transfemoral percutaneous pulmonary valve implantation of a 29 mm Edwards Sapien 3 valve without pre-stenting, followed by a six-week course of warfarin therapy for early leaflet thrombosis.
O
Outcome
Resolution of leaflet thickening on CT and reduction of transpulmonary valve peak gradient.surrogate
Early leaflet thrombosis complicating Sapien 3 valve implantation in a native RVOT can be successfully managed with oral anticoagulation.
Cite This Study
Riahi et al. (2017) conducted a case report in Severe symptomatic pulmonary regurgitation with severe RV dilatation (n=1). Transcatheter implantation of a 29 mm Edwards Sapien 3 valve was evaluated on Early leaflet thrombosis and peak pulmonary gradient. Transcatheter implantation of a Sapien 3 valve in a native right ventricular outflow tract was complicated by early leaflet thrombosis, which resolved after a 6-week course of warfarin therapy.