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Abstract The emergence of antifungal resistance emphasizes the need for alternative therapies such as antimicrobial photodynamic therapy (APDT). This study evaluates the APDT efficacy of silver-doped titanium dioxide (Ag–TiO₂) nanoparticles (NPs) against Candida albicans under blue-, green-, and red-light irradiation. Ag–TiO₂ NPs were synthesized via the sol–gel method and structurally and optically characterized. Among the tested conditions, blue-light irradiation of TiO₂:Ag2 at 31.75 µg/ml, a concentration within the low range compared to previously reported studies, achieved the highest APDT total efficacy that was of 60%. The overall inhibition efficacy gradually decreased as the doping concentration increased. Additionally, in this study, cellular inactivation was observed for the first time using red-light-mediated APDT against C. albicans with doped TiO₂. Based on these findings, we conclude that Ag-doped TiO₂ nanoparticles with low doping concentrations can be effective under visible light conditions, showing potential clinical relevance.
Lozano‐Rosas et al. (Mon,) studied this question.