Key result
Early autonomic dysfunction after TBI drives multiorgan dysfunction and increases morbidity.
Why the study?
Traumatic brain injury is a leading cause of injury-related disability and death, and extracranial organ involvement critically affects patient outcomes.
Does early autonomic dysfunction worsen multiple organ dysfunction in patients with traumatic brain injury?
Does early autonomic dysfunction worsen multiple organ dysfunction in patients with traumatic brain injury?
Recognizing early autonomic dysfunction in traumatic brain injury is critical as it initiates systemic changes leading to extracranial organ damage and poor outcomes.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to monitor for early autonomic dysfunction in moderate-severe TBI; leaves open whether targeted interventions reduce multiorgan morbidity.
Background/Objectives: Traumatic brain injury (TBI) is a complex condition and a leading cause of injury-related disability and death, with significant impacts on patient outcomes. Extracranial organ involvement plays a critical role in the outcome of patients following TBI. Method: This review aims to provide a comprehensive overview of the pathophysiology, clinical presentation, and challenges in diagnosing patients with autonomic dysfunction after TBI. The databases used in this review include PubMed/MEDLINE, Cochrane Central Register, and Scopus. Results: Of 172 articles identified for screening, 98 were ultimately included in the review. Conclusion: This review summarized the current evidence on the pathophysiology, clinical presentation, and diagnosis of early autonomic dysfunction. It also emphasizes the effects of autonomic dysfunction on end-organ damage. These insights aim to guide clinicians and researchers toward improving the care for and understanding of autonomic dysfunction in TBI patients, while underscoring the need for further research in this area.
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Wongsripuemtet et al. (2025) conducted a review in Traumatic brain injury with early autonomic dysfunction (n=98). Early autonomic dysfunction was evaluated on Pathophysiology, clinical presentation, and multiorgan dysfunction impact. Early autonomic dysfunction following moderate to severe traumatic brain injury drives systemic cascades that lead to multiorgan dysfunction and increased morbidity.
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