Disordered proteins in dementia

Aggregates of dysfunctional proteins and peptides in orAggregates of dysfunctional proteins and peptides in or between brain neurons are key neuropathological features between brain neurons are key neuropathological features of dementia and are believed to directly cause or substan-of dementia and are believed to directly cause or substantially contribute to the development of these diseases.tially contribute to the development of these diseases.Fundamental parts of the mechanisms underlying the Fundamental parts of the mechanisms underlying the dysregulation of proteins in Alzheimer's disease, fronto-dysregulation of proteins in Alzheimer's disease, frontotemporal dementia, prion diseases and other dementing temporal dementia, prion diseases and other dementing disorders are now well characterized, mainly due to the disorders are now well characterized, mainly due to the discovery of genes causing dominantly inherited disease discovery of genes causing dominantly inherited disease forms (Table 1).As of today, no efcient pharmacotherapies forms (Table 1).As of today, no efcient pharmacotherapies are available, but new insights into the underlying molecular are available, but new insights into the underlying molecular mechanisms are providing strategies to prevent or even cure mechanisms are providing strategies to prevent or even cure these devastating disorders.these devastating disorders.