Key result
Obstructive sleep apnea syndrome is considered an important risk factor for severe COVID-19, potentially worsening hypoxemia and cytokine storm, and early use of CPAP is recommended to prevent ARDS.
Why the study?
OSAS has been considered an important risk factor for severe Covid-19, sharing common comorbidities that increase mortality risk and involving renin-angiotensin system dysregulation.
This review highlights obstructive sleep apnea as a potential risk factor for severe COVID-19 and advocates for the early use of CPAP to prevent ARDS.
Answers are grounded in this paper and cite their sources.
OSAS may warrant risk stratification in COVID-19; leaves open independent prognostic value beyond comorbidities.
OSAS has been considered by some authors an important risk factor for severe Covid-19. Risk factors for mortality in COVID-19, such as cardiovascular and cerebrovascular complications or comorbidities, for example hypertension, heart failure, coronary artery disease, cerebrovascular diseases, diabetes mellitus, and obesity are commonly seen in OSAS patients. SARS-CoV-2 uses the ACE2 receptor for host cell entry, and augmented expression of ACE and dysregulation of the renin-angiotensin system in untreated OSAS patients, due to chronic intermittent hypoxia, has been shown.
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Calixto et al. (2020) conducted a review in COVID-19 and Obstructive Sleep Apnea Syndrome (OSAS). Obstructive Sleep Apnea Syndrome (OSAS) was evaluated. Obstructive sleep apnea syndrome is considered an important risk factor for severe COVID-19, potentially worsening hypoxemia and cytokine storm, and early use of CPAP is recommended to prevent ARDS.
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