Key result
Most patients with exertional rhabdomyolysis have no underlying disease and do not require investigation, whereas a small group with underlying muscle disease requires identification and investigation.
Why the study?
Which patients with exertional rhabdomyolysis require investigation for underlying muscle disease?
Which patients with exertional rhabdomyolysis require investigation for underlying muscle disease?
Provides guidance on distinguishing physiological exertional rhabdomyolysis from cases requiring investigation for underlying muscle disease.
Answers are grounded in this paper and cite their sources.
May limit unnecessary testing in exertional rhabdomyolysis; leaves open prospective validation of selection criteria.
Rhabdomyolysis is the combination of symptoms (myalgia, weakness and muscle swelling) and a substantial rise in serum creatine kinase (CK) >50 000 IU/L; there are many causes, but here we specifically address exertional rhabdomyolysis. The consequences of this condition can be severe, including acute kidney injury and requirement for higher level care with organ support. Most patients have 'physiological' exertional rhabdomyolysis with no underlying disease; they do not need investigation and should be advised to return to normal activities in a graded fashion. Rarely, exertional rhabdomyolysis may be the initial presentation of underlying muscle disease, and we review how to identify this much smaller group of patients, who do require investigation.
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Fernandes et al. (2018) conducted a review in Exertional rhabdomyolysis. Investigation of exertional rhabdomyolysis was evaluated. Most patients with exertional rhabdomyolysis have no underlying disease and do not require investigation, whereas a small group with underlying muscle disease requires identification and investigation.
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