What question did this study set out to answer?

This research aims to characterize a germ-line deletion affecting key tumor suppressor genes in a melanoma-NST family and identify associated noncoding RNAs.

April 15, 2007Cancer ResearchOpen Access

Characterization of a Germ-Line Deletion, Including the Entire INK4/ARF Locus, in a Melanoma-Neural System Tumor Family: Identification of ANRIL , an Antisense Noncoding RNA Whose Expression Coclusters with ARF

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Authors

ÉPÉric PasmantCentre National de la Recherche Scientifique ILIngrid LaurendeauCentre National de la Recherche Scientifique DHDelphine HéronCentre National de la Recherche Scientifique

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Implication

Randomized trial identifies ANRIL antisense RNA in melanoma-NST families, suggesting new genetic implications.

Key Points

This research aims to characterize a germ-line deletion affecting key tumor suppressor genes in a melanoma-NST family and identify associated noncoding RNAs.
Germ-line deletion identified using heterozygosity mapping with microsatellite markers.
Gene dose mapping was performed through sequence-tagged site real-time PCR.
The deletion end points were characterized using long-range PCR and nucleotide sequencing.
The germ-line deletion spans 403,231 bp, affecting p15/CDKN2B, p16/CDKN2A, and p14/ARF genes.
Identification of ANRIL, an antisense noncoding RNA, located within the deletion, with expression clustering with p14/ARF.
ANRIL expression observed in various normal human tissues and human breast tumors.

Cite This Study

Pasmant et al. (2007) studied this question.

synapsesocial.com/papers/6a6130de346eb5614926bc2e https://doi.org/10.1158/0008-5472.can-06-2004

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Characterization of a Germ-Line Deletion, Including the Entire INK4/ARF Locus, in a Melanoma-Neural System Tumor Family: Identification of ANRIL , an Antisense Noncoding RNA Whose Expression Coclusters with ARF

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Cite This Study

Characterization of a Germ-Line Deletion, Including the Entire INK4/ARF Locus, in a Melanoma-Neural System Tumor Family: Identification of ANRIL , an Antisense Noncoding RNA Whose Expression Coclusters with ARF

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