Key result
In over 95% of stenotic aortic valves, the etiology is congenital, degenerative, or rheumatic, while pure aortic regurgitation is most commonly caused by diseases affecting the aortic valve alone.
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This review categorizes the morphologic and histologic etiologies of pure aortic regurgitation into four distinct anatomical groups.
This two-part article examines the histologic and morphologic basis for stenotic and purely regurgitant aortic valves. Part I discussed stenotic aortic valves and Part II discusses causes of purely regurgitant aortic valves. In over 95% of stenotic aortic valves, the etiology is one of three types: congenital (primarily bicuspid), degenerative, and rheumatic. Other rare causes included active infective endocarditis, homozygous type II hyperlipoproteinemia, and systemic lupus erythematosis. The causes of pure aortic regurgitation are multiple but can be separated into diseases affecting the valve (normal aorta) (infective endocarditis, congenital bicuspid, rheumatic, floppy), diseases affecting the walls of aorta (normal valve) (syphilis, Marfan's dissection), disease affecting both aorta and valve (abnormal aorta, abnormal valve) (ankylosing spondylitis), and disease affecting neither aorta nor valve (normal aorta, normal valve) (ventricular septal defect, systemic hypertension). Diseases affecting the aortic valve alone are the most common subgroup of conditions producing purely regurgitant aortic valves.
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Waller et al. (1994) conducted a review in Aortic valve stenosis and pure aortic regurgitation. In over 95% of stenotic aortic valves, the etiology is congenital, degenerative, or rheumatic, while pure aortic regurgitation is most commonly caused by diseases affecting the aortic valve alone.
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