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envelope that has been modified by the insertion of two integral membrane glycoproteins, E (53 kDa) and prM (18-20 kDa). The virion is 45 nm to 50 nm in diameter (Figure Late in virus maturation, the prM protein is cleaved to M protein (8 kDa) by a cellular protease, and the M protein is incorporated into the mature virion. The genome also encodes seven nonstructural proteins (NS1, NS2a, NS2a, NS3, NS4a, NS4b, and NS5) that make up the intracellular replication machinery of the virus. E-glycoprotein, the most immunologically important structural protein, is the viral hemagglutinin West Nile Virus: A Reemerging Global
Petersen et al. (Wed,) studied this question.