Key result
Late-stage chronic kidney disease in breast cancer patients was associated with a significantly lower 5-year overall survival rate compared to patients with normal renal function (71.2% vs 90.1%, OR 5.211).
Why the study?
Because renally cleared chemotherapeutic regimens may cause nephrotoxicity in breast cancer due to comorbidities and multi-therapeutic modalities, the study aimed to compare chemotherapy types and outcomes in breast cancer patients with or without chronic renal disease.
Does late-stage chronic kidney disease affect treatment modalities and survival outcomes in female patients with breast cancer?
Cohort (n=124)
No
Does late-stage chronic kidney disease affect treatment modalities and survival outcomes in female patients with breast cancer?
Odds Ratio: 5.211 (95% CI 1.878–14.46)
Absolute Event Rate: 71.2% vs 90.1%
p-value: p=0.002
Breast cancer patients with late-stage CKD have lower overall survival but lower breast cancer-related mortality compared to those with normal renal function, indicating mortality is primarily driven by underlying renal disease.
Results in breast cancer with advanced CKD are hypothesis-generating; leaves open optimal chemotherapy selection pending prospective data.
BACKGROUND: Due to the presence of other comorbidities and multi-therapeutic modalities in breast cancer, renally cleared chemotherapeutic regimens may cause nephrotoxicity. The aim of this retrospective study is to compare the chemotherapy types and outcomes in breast cancer patients with or without chronic renal disease. PATIENTS AND METHODS: We retrospectively enrolled 62 female patients with breast cancer and underlying late stages (stage 3b, 4, and 5) of chronic kidney disease (CKD) treated from 2000 to 2017. They were propensity score-matched 1:1 with patients in our database with breast cancer and normal renal function (total n = 124). RESULTS: The main subtype of breast cancer was luminal A and relatively few patients with renal impairment received chemotherapy and anti-Her-2 treatment. The breast cancer patients with late-stage CKD had a slightly higher recurrent rate, especially at the locally advanced stage. The 5-year overall survival was 90.1 and 71.2% for patients without and with late-stage CKD, but the breast cancer-related mortality rate was 88.9 and 24.1%, respectively. In multivariate analyses, dose-reduced chemotherapy was an independent negative predictor of 5-year recurrence-free survival and late-stage CKD was associated with lower 5-year overall survival rate. CONCLUSIONS: Breast cancer patients with late-stage CKD may receive insufficient therapeutic modalities. Although the recurrence-free survival rate did not differ significantly by the status of CKD, patients with breast cancer and late-stage CKD had shorter overall survival time but a lower breast cancer-related mortality rate, indicated that the mortality was related to underlying disease.
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Hong et al. (2023) conducted a cohort in Breast cancer (n=124). Late-stage chronic kidney disease vs. Normal renal function was evaluated on 5-year overall survival (OR 5.211, 95% CI 1.878-14.460, p=0.002). Late-stage chronic kidney disease in breast cancer patients was associated with a significantly lower 5-year overall survival rate compared to patients with normal renal function (71.2% vs 90.1%, OR 5.211).
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