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This study aims to compare clinical characteristics and pain severity in seropositive and seronegative primary Sjögren's syndrome patients.

Pain Severity and Neuropathic Pain Symptoms in Primary Sjögren's Syndrome: A Comparison Study of Seropositive and Seronegative Sjögren's Syndrome Patients

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This study aims to compare clinical characteristics and pain severity in seropositive and seronegative primary Sjögren's syndrome patients.
Pain, comorbidity, and health status were assessed in 108 primary Sjögren's syndrome patients.
T-test and chi-square test were used to assess differences between groups.
Multivariate regression analyzed the effect of various predictors on pain severity.
Pain severity was significantly greater in seronegative patients (P = 0.003).
Prevalence of chronic pain was reported by 65% of seropositive and 75% of seronegative patients.
Significant difference in pain severity remained after adjusting for age, sleep quality, and psychological distress.

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Comparison study reveals differing pain severity in Sjögren's syndrome based on serologic status, implying targeted treatment needs.

Segal et al. (2013) studied this question.

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