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Abstract Carbon monoxide (CO) is an endogenous signaling molecule with broad therapeutic effects. Here, a multifunctional X‐ray‐triggered carbon monoxide (CO) and manganese dioxide (MnO 2 ) generation nanoplatform based on metal carbonyl and scintillating nanoparticles (SCNPs) is reported. Attributed to the radioluminescent characteristic of SCNPs, UV‐responsive Mn 2 (CO) 10 is not only indirectly activated to release CO by X‐ray but can also be degraded into MnO 2 . A high dose of CO can be used as a glycolytic inhibitor for tumor suppression; it will also sensitize tumor cells to radiotherapy. Meanwhile MnO 2 , as the photolytic byproduct of Mn 2 (CO) 10 , has both glutathione (GSH) depletion and Fenton‐like Mn 2+ delivery properties to produce highly toxic hydroxyl radical (⋅OH) in tumors. Thus, this strategy can realize X‐ray‐activated CO release, GSH depletion, and ⋅OH generation for cascade cancer radiosensitization. Furthermore, X‐ray‐activated Mn 2+ in vivo demonstrates an MRI contrast effect, making it a potential theranostic nanoplatform.
Du et al. (Fri,) studied this question.