Key points are not available for this paper at this time.
The first total synthesis of the sesterterpenoid (−)-calidoustene has been accomplished, featuring a stereoselective Michael/aldol cascade to construct the trans -hydrindane backbone, a tandem Pummerer/Sakurai cyclization to establish the bicyclo3.2.1octane framework, a metallaphotoredox enone coupling followed by MHAT-initiated cyclization to forge the congested central C-ring, and late-stage functionalization via Cu-catalyzed desaturation and diimide reduction.
Yao et al. (Tue,) studied this question.