Recent Advances on the Construction of Functionalized Indolizine and Imidazo1,2‐apyridine Derivatives

Indolizines and imidazo1,2-apyridines are commonly found in natural products, synthetic drugs, and bioactive molecules. These two types of derivatives possess good antibacterial, antiparasitic, anticancer activities, and so on. The functionalization of indolizines and imidazo1,2-apyridines has always been a hot topic in organic chemistry research and has made significant progress. In recent years, our group has been dedicated to developing diverse synthetic methods for the preparation of such important compounds. 1) We have developed diverse C-H functionalization reactions for efficient modification of the parent indolizines and imidazo1,2-apyridines. 2) A variety of cycloaddition reactions were established for the construction of indolizine and imidazo1,2-apyridine derivatives from simple raw materials. 3) We have developed intriguing deconstruction-functionalization reactions of indolizines, enabling the reorganization of heterocyclic frameworks. This paper outlines our group's latest advancements in constructing structurally diverse indolizine and imidazo1,2-apyridine derivatives. We hope that this work will offer valuable insights and inspiration for the ongoing research in the field of N-heterocyclic compounds.