Key result
Extracellular vesicles transport bioactive molecules during viral infections and can cause thrombosis through abnormal enhancement of the coagulatory system.
Why the study?
Abnormal enhancement of the coagulatory system through extracellular vesicles can cause thrombosis, warranting a review of their functions and involvement in viral infection.
Extracellular vesicles may play a key role in the pathogenesis of thrombosis associated with viral infections such as COVID-19.
May link EVs to viral thrombosis risk; leaves open targeted interventions pending prospective trials.
Although the outcomes of viral infectious diseases are remarkably varied, most infections cause acute diseases after a short period. Novel coronavirus disease 2019, which recently spread worldwide, is no exception. Extracellular vesicles (EVs) are small circulating membrane-enclosed entities shed from the cell surface in response to cell activation or apoptosis. EVs transport various kinds of bioactive molecules between cells, including functional RNAs, such as viral RNAs and proteins. Therefore, when EVs are at high levels, changes in cell activation, inflammation, angioplasty and transportation suggest that EVs are associated with various diseases. Clinical research on EVs includes studies on the coagulatory system. In particular, abnormal enhancement of the coagulatory system through EVs can cause thrombosis. In this review, we address the functions of EVs, thrombosis, and their involvement in viral infection.
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Nomura et al. (2020) conducted a review in Viral infection and thrombosis. Extracellular vesicles was evaluated. Extracellular vesicles transport bioactive molecules during viral infections and can cause thrombosis through abnormal enhancement of the coagulatory system.
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