Key result
Depressive symptoms were inversely associated with nucleus accumbens volume (β = -0.217, p = 0.008) in women with BMI ≥ 25 kg/m2, but with insula volume (β = -0.147, p = 0.027) in women with BMI < 25 kg/m2.
Why the study?
Data are limited on how different brain structures associate with depressive symptoms and body composition in women who are obese/overweight versus normal-/underweight.
Cross-Sectional (n=265)
No
Depressive symptoms are associated with reduced nucleus accumbens volume in overweight/obese women, whereas in normal/underweight women they are associated with reduced insula volume.
Answers are grounded in this paper and cite their sources.
May indicate BMI-moderated brain-depression links in women; hypothesis-generating, requires prospective validation before clinical consideration.
Depressive symptoms are highly prevalent and heterogeneous in women. Different brain structures might be associated with depressive symptoms and body composition in women with obesity/overweight and normal-/underweight, although the data is limited. The analysis included 265 women from Bialystok PLUS population study, untreated with antidepressive or antipsychotic medications. The subjects underwent brain magnetic resonance imaging and body composition analysis. Beck Depression Inventory (BDI) score was inversely associated with nucleus accumbens volume (β = −0.217, p = 0.008) in women with BMI ≥ 25 kg/m 2 , but with insula volume (β = −0.147, p = 0.027) in women with BMI < 25 kg/m 2 after adjustment for age and estimated intracranial volume (eTIV). In women with BMI ≥ 25 kg/m 2 , nucleus accumbens volume was inversely associated with the percentage of visceral fat and BDI score (β = −0.236, p = 0.012, β = −0.192, p = 0.017) after adjustment for age and eTIV. In women with BMI < 25 kg/m 2 , insula volume was positively associated with total fat-free mass and negatively with the BDI score (β = 0.142, p = 0.030, β = −0.137, p = 0.037) after adjustment for age and eTIV. Depressive symptoms might be associated with nucleus accumbens volume in overweight/obese women, while in normal-/ underweight women—with alterations in insula volume.
No takes yet. Share an insight, caveat, or question.
Łapińska et al. (2024) conducted a cross-sectional in Depressive symptoms and obesity (n=265). Obesity/overweight (BMI ≥ 25 kg/m2) vs. Normal-/underweight (BMI < 25 kg/m2) was evaluated on Association between Beck Depression Inventory (BDI) score and nucleus accumbens volume in women with BMI ≥ 25 kg/m2 (β = -0.217, p=0.008). Depressive symptoms were inversely associated with nucleus accumbens volume (β = -0.217, p = 0.008) in women with BMI ≥ 25 kg/m2, but with insula volume (β = -0.147, p = 0.027) in women with BMI < 25 kg/m2.
Synapse has enriched 10 related papers. Consider them for comparative context: