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This research aims to compare the clinical efficacy of different COVID-19 vaccines in preventing symptomatic and severe disease.

November 23, 2021Scientific ReportsOpen Access

Comparing the clinical efficacy of COVID-19 vaccines: a systematic review and network meta-analysis

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Systematic review compares the efficacy of COVID-19 vaccines in adults and the elderly, suggesting implications for vaccine choice.

This research aims to compare the clinical efficacy of different COVID-19 vaccines in preventing symptomatic and severe disease.
Performed a systematic review and network meta-analysis of phase 3 randomized controlled trials.
Evaluated literature from leading medical databases until August 30, 2021.
Included over 200,000 adult participants across eight trials with efficacy assessed against symptomatic COVID-19.
BNT162b2 and mRNA-1273 vaccines showed the highest probabilities of efficacy (P-scores 0.952 and 0.843).
No significant differences in preventing symptomatic disease in the elderly population were observed.
mRNA-1273 and Gam-COVID-Vac exhibited the highest P-scores for protection against severe COVID-19.

Rotshild et al. (2021) studied this question.

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