Key result
TNF-alpha exerted a dose-dependent biphasic effect on cardiomyocyte calcium transients and contraction, mediated by the cytosolic PLA2/arachidonic acid pathway.
Population
electrically stimulated adult rat cardiac myocytes
Design
Preclinical
Follow-up
40 min
Authors
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Does not support clinical translation from rat myocytes; leaves open AA mediation of TNF-alpha effects in humans.
The cytosolic PLA2/arachidonic acid pathway plays a key role in mediating the biphasic contractile effects of TNF-alpha in adult rat cardiomyocytes.
Amadou et al. (2002) studied Healthy adult rat cardiac myocytes. Tumor necrosis factor (TNF)-alpha was evaluated on [Ca2+]i transients and contraction. TNF-alpha exerted a dose-dependent biphasic effect on cardiomyocyte calcium transients and contraction, mediated by the cytosolic PLA2/arachidonic acid pathway.
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