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Contents Introduction Optimization of the catalytic properties of single enzymes Irreversible two‐step kinetic mechanism Reversible three‐step kinetic mechanism Cooperative enzymes Optimization of multienzyme systems Basic equations for unbranched reaction chains Maximization ofsteady‐state fluxes Transient times Sensitivity to external signals Implications of the solvent capacity and osmotic balance Metabolic channelling Thermodynamic principles Optimal stoichiometries Time hierarchy in biochemical networks Final remarks
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Heinrich et al. (1991) studied this question.
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