Key result
Current literature suggests early surgery for infective endocarditis with uncomplicated ischemic stroke may carry a lower risk of hemorrhagic conversion than recurrent embolism with delayed surgery.
Why the study?
When infective endocarditis is complicated by a neurologic event, guideline-recommended postponement of surgery can negatively impact patients needing urgent surgery, and literature is ambiguous regarding the safety of cardiopulmonary bypass.
Does early surgical intervention improve outcomes compared to postponement in patients with infective endocarditis complicated by a neurologic event?
Does early surgical intervention improve outcomes compared to postponement in patients with infective endocarditis complicated by a neurologic event?
This review suggests that early surgery for infective endocarditis complicated by uncomplicated ischemic stroke may carry a lower risk of hemorrhagic conversion than the risk of recurrent embolism with delayed surgery, challenging current guidelines.
Answers are grounded in this paper and cite their sources.
Supports weighing early surgery in IE with uncomplicated stroke to minimize embolism risk; leaves open need for prospective trials to guide timing.
A therapeutic dilemma arises when infective endocarditis (IE) is complicated by a neurologic event. Postponement of surgery up to 4 weeks is recommended by the guidelines, however, this negatively impacts outcomes in many patients with an urgent indication for surgery due to uncontrolled infection, disease progression, or haemodynamic deterioration. The current literature is ambiguous regarding the safety of cardiopulmonary bypass in patients with recent neurologic injury. Nevertheless, most publications demonstrate a lower risk for secondary haemorrhagic conversion of uncomplicated ischaemic lesions than the risk for recurrent embolism under antibiotic treatment. Here, we discuss the current literature regarding neurologic stroke complicating IE with an indication for surgery.
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Bonaros et al. (2020) conducted a review in Infective endocarditis complicated by a neurologic event. Early surgical intervention vs. Postponement of surgery up to 4 weeks was evaluated. Current literature suggests early surgery for infective endocarditis with uncomplicated ischemic stroke may carry a lower risk of hemorrhagic conversion than recurrent embolism with delayed surgery.
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