Key result
Balloon dilatation of stenotic bioprosthetic porcine valves in the pulmonary position reduced the average valve gradient from 47.5 to 27 mm Hg in four children.
Why the study?
Does balloon dilatation reduce valve gradient in children with stenotic bioprosthetic porcine valves in the pulmonary position?
Case Report (n=4)
Does balloon dilatation reduce valve gradient in children with stenotic bioprosthetic porcine valves in the pulmonary position?
Absolute Event Rate: 27% vs 47.5%
Balloon dilatation can effectively reduce valve gradients in stenotic bioprosthetic pulmonary valves without causing structural damage, potentially deferring the need for conduit replacement.
May offer nonsurgical relief for failing pulmonary bioprostheses in children; leaves open durability, safety, and need for prospective trials.
Balloon dilatation (BD) of bioprosthetic valves was investigated in vivo and in vitro. Four children with stenotic bioprosthetic porcine valves in the pulmonary position underwent BD of the valve 10 to 24 months after its insertion. Average valve gradient was reduced from 47.5 to 27 mm Hg. Obstruction at the conduit-branch pulmonary artery connection became apparent after dilatation of the valve. These distal stenoses were also dilated. BD technique was tested in vitro with the use of nonstenotic valves in fresh conduits. No damage to the valve or to the conduit was found when oversized balloons were used in a standard fashion or intentionally inflated until rupture. It is concluded that conduit replacement may be deferred by balloon dilatation of obstructed biological valves and/or a stenotic conduit-pulmonary artery anastomosis.
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Waldman et al. (1987) conducted a case report in Stenotic bioprosthetic porcine valves in the pulmonary position (n=4). Balloon dilatation vs. Pre-intervention baseline was evaluated on Average valve gradient. Balloon dilatation of stenotic bioprosthetic porcine valves in the pulmonary position reduced the average valve gradient from 47.5 to 27 mm Hg in four children.
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