Key result
A CM/VLDL-TG ratio ≥4.5 showed the greatest sensitivity, specificity, agreement, and predictive values for diagnosing Type I hyperlipoproteinemia in patients with severe hypertriglyceridemia.
Why the study?
The study sought to confirm the diagnostic performance of the CM/VLDL-TG ratio, the TG/TC ratio, and a dichotomic rule including the TG/APOB ratio for identifying Type I hyperlipoproteinemia in patients with severe hypertriglyceridemia at high risk for familial chylomicronemia syndrome.
Do lipid ratios (CM/VLDL-TG, TG/TC, TG/APOB) accurately diagnose Type I hyperlipoproteinemia in patients with severe hypertriglyceridemia?
Population
Patients with severe hypertriglyceridemia at high risk for familial chylomicronemia syndrome across derivation and validation cohorts
Comparison
CM/VLDL-TG ratio vs TG/TC ratio vs TG/APOB ratio
Design
Derivation and validation cohort diagnostic performance study
Authors
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May aid FCS screening in sHTG; leaves open prospective validation before clinical adoption.
Cohort
Do lipid ratios (CM/VLDL-TG, TG/TC, TG/APOB) accurately diagnose Type I hyperlipoproteinemia in patients with severe hypertriglyceridemia?
A CM/VLDL-TG ratio ≥4.5 is a strong diagnostic criterion for Type I hyperlipoproteinemia in patients with severe hypertriglyceridemia at high risk for familial chylomicronemia syndrome.
Rioja et al. (2020) conducted a cohort in Severe hypertriglyceridemia (sHTG) at high risk for familial chylomicronemia syndrome (FCS). CM/VLDL-TG ratio vs. TG/TC and TG/APOB ratios was evaluated on Presence of Type I hyperlipoproteinemia (HPLI). A CM/VLDL-TG ratio ≥4.5 showed the greatest sensitivity, specificity, agreement, and predictive values for diagnosing Type I hyperlipoproteinemia in patients with severe hypertriglyceridemia.
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