The Tolbutamide Controversy: A Personal Perspective

Perspective1 August 1971The Tolbutamide Controversy: A Personal PerspectiveTHEODORE B. SCHWARTZ, M.D., F.A.C.P.THEODORE B. SCHWARTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-2-303 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is only with some difficulty that even the older clinician can recall the days before the advent of tolbutamide for the treatment of maturity-onset diabetes. This is because tolbutamide, other sulfonylureas, and the biguanides have entrenched themselves as highly satisfactory therapeutic agents. Until 13 years ago the treatment of the adult-onset, obese diabetic often evolved into a battle between a concerned physician, who sternly offered the alternatives of prodigious weight loss and daily insulin injections, and a reluctant patient whose mood ranged from anxiety and hostility through desperation and despair. Despite early cautionary voices, the oral hypoglycemic agents were...References1. : A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. Diabetes 19(suppl 2):747-830, 1970 Google Scholar2. Medical Tribune and Medical News, Vol. 5, No. 3, 22 February 1971 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois▸From the Section of Endocrinology and Metabolism, Presbyterian-St. Luke's Hospital, Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe trials and tribulations of the University Group Diabetes Program 2: lessons and reflectionsFact versus Conjecture: Exploring Levels of Evidence in the Context of Patient Safety and Care QualityControl materials and light coolant cross-section dataMortality from Coronary Heart Disease During Phenformin TherapyMANUEL TZAGOURNIS, M.D., RICHARD REYNERTSON, M.D. 1 August 1971Volume 75, Issue 2Page: 303-306KeywordsAnxietyEndocrinologyHypoglycemicsInsulinOverweightType 2 diabetesWeight loss Issue Published: 1 August 1971 PDF DownloadLoading ...