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July 23, 2026eLifeOpen Access

DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2, and -3

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Authors

CNCrystal R. NoellTMTzu-Chen MaRJRui Jiang

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Overview

Randomized trial reveals detachment kinetics of kinesin families under load in vitro, indicating competition mechanisms.

Key Points

  • This study aims to investigate the detachment and reattachment kinetics of kinesin families under load using a DNA tensiometer.
  • Created a DNA tensiometer with an entropic spring and microtubule attachment.
  • Analyzed detachment rates of kinesin-1, -2, and -3 at varying loads and orientations.
  • Used stochastic simulations to compare transition rates among kinesin families.
  • Kinesin dissociation rates at stall were slower than those during unloaded runs.
  • Kinesin-3 exhibited long run lengths due to concatenation of short runs.
  • Stochastic simulations recapitulated load-dependent behaviors for all kinesin families.

Cite This Study

Noell et al. (2026) studied this question.

synapsesocial.com/papers/6a61ae6bfaa9903c51169a6fhttps://doi.org/10.7554/elife.108837.4
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