Key result
Acute myocardial infarction was associated with significantly decreased circulating miR-409-5p and increased USP7 mRNA levels compared to chronic coronary syndrome, both of which strongly predicted left ventricular remodeling at 6 weeks.
Why the study?
Following animal findings linking miR-409-5p and USP7 to ischemic left ventricular remodeling, their relationship with remodeling and dysfunction in AMI patients remained to be investigated.
Are circulating miR-409-5p and USP7 levels associated with left ventricular remodeling and dysfunction in patients with acute myocardial infarction?
Population
60 patients with AMI and 60 cases with CCS
Comparison
AMI vs CCS and admission vs 6 weeks after discharge
Design
Observational cohort study
Follow-up
6 weeks after discharge
Authors
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Plasma miR-409-5p and USP7 levels may associate with post-AMI LVR; leaves open biomarker utility pending prospective validation.
Observational (n=120)
No
Are circulating miR-409-5p and USP7 levels associated with left ventricular remodeling and dysfunction in patients with acute myocardial infarction?
Absolute Event Rate: 0.93% vs 1%
p-value: p=< 0.01
Circulating miR-409-5p and USP7 levels are dynamically altered after acute myocardial infarction and correlate with echocardiographic and biomarker indices of left ventricular remodeling.
He et al. (2024) conducted an observational in Acute myocardial infarction (n=120). Acute myocardial infarction vs. Chronic coronary syndrome was evaluated on Relative expression of circulating miR-409-5p at baseline (p=< 0.01). Acute myocardial infarction was associated with significantly decreased circulating miR-409-5p and increased USP7 mRNA levels compared to chronic coronary syndrome, both of which strongly predicted left ventricular remodeling at 6 weeks.
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